Bai, X.-c. Seeing atoms by single-particle Cryo-EM. Trends in biochemical sciences, 2021, 46, 253-254
Nakane et al. and Yip et al., for the first time, demonstrate that, with recent technological advances, atomic-resolution structure determination can be achieved by single-particle cryo-electron microscopy (cryo-EM). This breakthrough opens the door for researchers to apply single-particle cryo-EM to obtain atomic structural information for a wide range of protein complexes.