https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2012Zhang_PositiveStaining 2026-05-24T20:15:43Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2012Zhang_PositiveStaining&diff=2989&oldid=prev 2016-10-21T14:05:54Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:05, 21 October 2016</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l11">Line 11:</td> <td colspan="2" class="diff-lineno">Line 11:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Links ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Links ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>http://<del style="font-weight: bold; text-decoration: none;">foundry</del>.<del style="font-weight: bold; text-decoration: none;">lbl</del>.<del style="font-weight: bold; text-decoration: none;">gov</del>/<del style="font-weight: bold; text-decoration: none;">rengroup</del>/<del style="font-weight: bold; text-decoration: none;">page5</del>/<del style="font-weight: bold; text-decoration: none;">assets</del>/<del style="font-weight: bold; text-decoration: none;">CETP-NCB-2012-</del>full<del style="font-weight: bold; text-decoration: none;">-low</del>.<del style="font-weight: bold; text-decoration: none;">pdf</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>http://<ins style="font-weight: bold; text-decoration: none;">www</ins>.<ins style="font-weight: bold; text-decoration: none;">nature</ins>.<ins style="font-weight: bold; text-decoration: none;">com</ins>/<ins style="font-weight: bold; text-decoration: none;">nchembio</ins>/<ins style="font-weight: bold; text-decoration: none;">journal</ins>/<ins style="font-weight: bold; text-decoration: none;">v8/n4</ins>/full<ins style="font-weight: bold; text-decoration: none;">/nchembio.796</ins>.<ins style="font-weight: bold; text-decoration: none;">html</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Related software ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Related software ==</div></td></tr> </table>

CoSS https://3demmethods.i2pc.es/index.php?title=2012Zhang_PositiveStaining&diff=2988&oldid=prev 2016-10-21T14:05:24Z

<p>Created page with &quot;== Citation == Zhang, L.; Yan, F.; Zhang, S.; Lei, D.; Charles, M. A.; Cavigiolio, G.; Oda, M.; Krauss, R. M.; Weisgraber, K. H.; Rye, K.-A.; Pownall, H. J.; Qiu, X. &amp; Ren, G...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> Zhang, L.; Yan, F.; Zhang, S.; Lei, D.; Charles, M. A.; Cavigiolio, G.; Oda, M.; Krauss, R. M.; Weisgraber, K. H.; Rye, K.-A.; Pownall, H. J.; Qiu, X. &amp; Ren, G. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nature chemical biology, 2012, 8, 342-349<br /> <br /> == Abstract ==<br /> <br /> Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism. Delineating this mechanism would be an important step toward the rational design of new CETP inhibitors for treating cardiovascular diseases. Using EM, single-particle image processing and molecular dynamics simulation, we discovered that CETP bridges a ternary complex with its N-terminal β-barrel domain penetrating into high-density lipoproteins and its C-terminal domain interacting with low-density lipoprotein or very-low-density lipoprotein. In our mechanistic model, the CETP lipoprotein-interacting regions, which are highly mobile, form pores that connect to a hydrophobic central cavity, thereby forming a tunnel for transfer of neutral lipids from donor to acceptor lipoproteins. These new insights into CETP transfer provide a molecular basis for analyzing mechanisms for CETP inhibition.<br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> http://foundry.lbl.gov/rengroup/page5/assets/CETP-NCB-2012-full-low.pdf<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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