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2016-09-02T05:17:25Z

Created page with "== Citation == Ye, K. & Lim, L. H. Cohomology of cryo-electron Microscopy Arxiv, 2016 == Abstract == The goal of cryo-electron microscopy (EM) is to reconstruct the 3-dimen..."

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== Citation ==

Ye, K. & Lim, L. H. Cohomology of cryo-electron Microscopy Arxiv, 2016

== Abstract ==

The goal of cryo-electron microscopy (EM) is to reconstruct the 3-dimensional structure
of a molecule from a collection of its 2-dimensional projected images. In this article, we show
that the basic premise of cryo-EM | patching together 2-dimensional projections to reconstruct
a 3-dimensional object | is naturally one of �Cech cohomology with SO(2)-coe�cients. We deduce
that every cryo-EM reconstruction problem corresponds to an oriented circle bundle on a
simplicial complex, allowing us to classify cryo-EM problems via principal bundles. In practice, the
2-dimensional images are noisy and a main task in cryo-EM is to denoise them. We will see how
the aforementioned insights can be used towards this end.

== Keywords ==

== Links ==

https://arxiv.org/pdf/1604.01319v1.pdf

== Related software ==

== Related methods ==

== Comments ==

2016Ye Cohomology - Revision history

CoSS: Created page with "== Citation == Ye, K. & Lim, L. H. Cohomology of cryo-electron Microscopy Arxiv, 2016 == Abstract == The goal of cryo-electron microscopy (EM) is to reconstruct the 3-dimen..."