https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2017Frazier_Tomominer 2026-05-24T19:52:55Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2017Frazier_Tomominer&diff=3109&oldid=prev 2017-06-19T05:38:22Z

<p>Created page with &quot;== Citation == Frazier, Z.; Xu, M. &amp; Alber, F. TomoMiner and TomoMinerCloud: A Software Platform for Large-Scale Subtomogram Structural Analysis. Structure, 2017, 25, 951-961...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> Frazier, Z.; Xu, M. &amp; Alber, F. TomoMiner and TomoMinerCloud: A Software Platform for Large-Scale Subtomogram Structural Analysis. Structure, 2017, 25, 951-961.e2<br /> <br /> == Abstract ==<br /> <br /> Cryo-electron tomography (cryo-ET) captures the 3D electron density distribution of macromolecular complexes in close to native state. With the rapid advance of cryo-ET acquisition technologies, it is possible to generate large numbers (&gt;100,000) of subtomograms, each containing a macromolecular complex. Often, these subtomograms represent a heterogeneous sample due to variations in the structure and composition of a complex in situ form or because particles are a mixture of different complexes. In this case subtomograms must be classified. However, classification of large numbers of subtomograms is a time-intensive task and often a limiting bottleneck. This paper introduces an open source software platform, TomoMiner, for large-scale subtomogram classification, template matching, subtomogram averaging, and alignment. Its scalable and robust parallel processing allows efficient classification of tens to hundreds of thousands of subtomograms. In addition, TomoMiner provides a pre-configured TomoMinerCloud computing service permitting users without sufficient computing resources instant access to TomoMiners high-performance features.<br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> https://www.ncbi.nlm.nih.gov/pubmed/28552576<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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