WikiSysop: Created page with "== Citation == Bell, J. M.; Chen, M.; Durmaz, T.; Fluty, A. C. & Ludtke, S. J. New software tools in EMAN2 inspired by EMDatabank map challenge. Journal of structural biolog..."

2019-07-02T05:26:56Z

Created page with "== Citation == Bell, J. M.; Chen, M.; Durmaz, T.; Fluty, A. C. & Ludtke, S. J. New software tools in EMAN2 inspired by EMDatabank map challenge. Journal of structural biolog..."

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== Citation ==

Bell, J. M.; Chen, M.; Durmaz, T.; Fluty, A. C. & Ludtke, S. J.
New software tools in EMAN2 inspired by EMDatabank map challenge.
Journal of structural biology, 2018 , 204 , 283-290

== Abstract ==

EMAN2 is an extensible software suite with complete workflows for performing high-resolution single particle analysis, 2-D and 3-D heterogeneity analysis, and subtomogram averaging, among other tasks. Participation in the recent CryoEM Map Challenge sponsored by the EMDatabank led to a number of significant improvements to the single particle analysis process in EMAN2. A new convolutional neural network particle picker was developed, which dramatically improves particle picking accuracy for difficult data sets. A new particle quality metric capable of accurately identifying "bad" particles with a high degree of accuracy, no human input, and a negligible amount of additional computation, has been introduced, and this now serves as a replacement for earlier human-biased methods. The way 3-D single particle reconstructions are filtered has been altered to be more comparable to the filter applied in several other popular software packages, dramatically improving the appearance of sidechains in high-resolution structures. Finally, an option has been added to perform local resolution-based iterative filtration, resulting in local resolution improvements in many maps.

== Keywords ==

== Links ==

https://www.sciencedirect.com/science/article/pii/S1047847718302521

== Related software ==

== Related methods ==

== Comments ==

2018Bell EMAN2 - Revision history

WikiSysop: Created page with "== Citation == Bell, J. M.; Chen, M.; Durmaz, T.; Fluty, A. C. & Ludtke, S. J. New software tools in EMAN2 inspired by EMDatabank map challenge. Journal of structural biolog..."