https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2021Sorzano_PCA 2026-06-13T13:45:37Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2021Sorzano_PCA&diff=3990&oldid=prev 2021-05-26T10:59:45Z

<p>Created page with &quot;== Citation == Sorzano, C. O. S. &amp; Carazo, J. M. Principal component analysis is limited to low-resolution analysis in cryoEM. Acta Crystallographica Section D, 2021, 77...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> Sorzano, C. O. S. &amp;amp; Carazo, J. M. Principal component analysis is limited to low-resolution analysis in cryoEM. Acta Crystallographica Section D, 2021, 77<br /> <br /> == Abstract ==<br /> <br /> Principal component analysis (PCA) has been widely proposed to analyze flexibility and heterogeneity in cryo-electron microscopy (cryoEM). In this paper, it is argued that (i) PCA is an excellent technique to describe continuous flexibility at low resolution (but not so much at high resolution) and (ii) PCA components should be analyzed in a concerted manner (and not independently). <br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> https://scripts.iucr.org/cgi-bin/paper?S2059798321002291<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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