https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2022Guaita_Review 2026-05-24T20:20:11Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2022Guaita_Review&diff=4368&oldid=prev 2023-07-18T07:13:38Z

<p>Created page with &quot;== Citation == Guaita, Margherita / Watters, Scott C. / Loerch, Sarah. Recent advances and current trends in cryo-electron microscopy. 2022. Current opinion in structural bio...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> Guaita, Margherita / Watters, Scott C. / Loerch, Sarah. Recent advances and current trends in cryo-electron microscopy. 2022. Current opinion in structural biology, Vol. 77, p. 102484 <br /> <br /> == Abstract ==<br /> <br /> All steps of cryogenic electron-microscopy (cryo-EM) workflows<br /> have rapidly evolved over the last decade. Advances in<br /> both single-particle analysis (SPA) cryo-EM and cryo-electron<br /> tomography (cryo-ET) have facilitated the determination of<br /> high-resolution biomolecular structures that are not tractable<br /> with other methods. However, challenges remain. For SPA,<br /> these include improved resolution in an additional dimension:<br /> time. For cryo-ET, these include accessing difficult-to-image<br /> areas of a cell and finding rare molecules. Finally, there is a<br /> need for automated and faster workflows, as many projects are<br /> limited by throughput. Here, we review current developments in<br /> SPA cryo-EM and cryo-ET that push these boundaries.<br /> Collectively, these advances are poised to propel our spatial<br /> and temporal understanding of macromolecular processes.<br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> https://www.sciencedirect.com/science/article/pii/S0959440X22001634<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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