WikiSysop: Created page with "== Citation == Herreros, D. / Krieger, J. M. / Fonseca, Y. / Conesa, P. / Harastani, M. / Vuillemot, R. / Hamitouche, I. / Serrano Gutiérrez, R. / Gragera, M. / Melero, R. /..."

2023-09-11T07:14:57Z

Created page with "== Citation == Herreros, D. / Krieger, J. M. / Fonseca, Y. / Conesa, P. / Harastani, M. / Vuillemot, R. / Hamitouche, I. / Serrano Gutiérrez, R. / Gragera, M. / Melero, R. /..."

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== Citation ==

Herreros, D. / Krieger, J. M. / Fonseca, Y. / Conesa, P. / Harastani, M. / Vuillemot, R. / Hamitouche, I. / Serrano Gutiérrez, R. / Gragera, M. / Melero, R. / others
Scipion Flexibility Hub: an integrative framework for advanced analysis of conformational heterogeneity in cryoEM. 2023. Acta Crystallographica Section D: Structural Biology, Vol. 79, No. 7

== Abstract ==

Understanding how structure and function meet to drive biological processes is
progressively shifting the cryoEM field towards a more advanced analysis of
macromolecular flexibility. Thanks to techniques such as single-particle analysis
and electron tomography, it is possible to image a macromolecule in different
states, information that can subsequently be extracted through advanced image processing
methods to build a richer approximation of a conformational
landscape. However, the interoperability of all of these algorithms remains a
challenging task that is left to users, preventing them from defining a single
flexible workflow in which conformational information can be addressed by
different algorithms. Therefore, in this work, a new framework integrated into
Scipion is proposed called the Flexibility Hub. This framework automatically
handles intercommunication between different heterogeneity software, simplifying
the task of combining the software into workflows in which the quality and
the amount of information extracted from flexibility analysis is maximized.

== Keywords ==

== Links ==

https://scripts.iucr.org/cgi-bin/paper?ic5121

== Related software ==

== Related methods ==

== Comments ==

2023Herreros Hub - Revision history

WikiSysop: Created page with "== Citation == Herreros, D. / Krieger, J. M. / Fonseca, Y. / Conesa, P. / Harastani, M. / Vuillemot, R. / Hamitouche, I. / Serrano Gutiérrez, R. / Gragera, M. / Melero, R. /..."