WikiSysop: Created page with "== Citation == Lucas, Bronwyn A. Visualizing everything, everywhere, all at once: Cryo-EM and the new field of structureomics. 2023. Current Opinion in Structural Biology, Vo..."

2023-09-26T07:39:45Z

Created page with "== Citation == Lucas, Bronwyn A. Visualizing everything, everywhere, all at once: Cryo-EM and the new field of structureomics. 2023. Current Opinion in Structural Biology, Vo..."

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== Citation ==

Lucas, Bronwyn A. Visualizing everything, everywhere, all at once: Cryo-EM and the new field of structureomics. 2023. Current Opinion in Structural Biology, Vol. 81, p. 102620

== Abstract ==

Twenty years ago, the release of the first draft of the human
genome sequence instigated a paradigm shift in genomics and
molecular biology. Arguably, structural biology is entering an
analogous era, with availability of an experimentally determined
or predicted molecular model for almost every proteincoding
gene from many genomes—producing a reference
“structureome”. Structural predictions require experimental
validation and not all proteins conform to a single structure,
making any reference structureome necessarily incomplete.
Despite these limitations, a reference structureome can be
used to characterize cell state in more detail than by quantifying
sequence or expression levels alone. Cryogenic electron
microscopy (cryo-EM) is a method that can generate atomic
resolution views of molecules and cells frozen in place. In this
perspective I consider how emerging cryo-EM methods are
contributing to the new field of structureomics.

== Keywords ==

== Links ==

https://www.sciencedirect.com/science/article/pii/S0959440X23000945

== Related software ==

== Related methods ==

== Comments ==

2023Lucas Structureome - Revision history

WikiSysop: Created page with "== Citation == Lucas, Bronwyn A. Visualizing everything, everywhere, all at once: Cryo-EM and the new field of structureomics. 2023. Current Opinion in Structural Biology, Vo..."