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2023-08-14T06:50:48Z

Created page with "== Citation == Millán, Claudia / McCoy, Airlie J. / Terwilliger, Thomas C. / Read, Randy J. Likelihood-based docking of models into cryo-EM maps. 2023. Acta Crystallographic..."

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== Citation ==

Millán, Claudia / McCoy, Airlie J. / Terwilliger, Thomas C. / Read, Randy J. Likelihood-based docking of models into cryo-EM maps. 2023. Acta Crystallographica Section D: Structural Biology, Vol. 79. p. 281-289

== Abstract ==

Optimized docking of models into cryo-EM maps requires exploiting an
understanding of the signal expected in the data to minimize the calculation time
while maintaining sufficient signal. The likelihood-based rotation function used
in crystallography can be employed to establish plausible orientations in a
docking search. A phased likelihood translation function yields scores for the
placement and rigid-body refinement of oriented models. Optimized strategies
for choices of the resolution of data from the cryo-EM maps to use in the
calculations and the size of search volumes are based on expected loglikelihood-
gain scores computed in advance of the search calculation. Tests
demonstrate that the new procedure is fast, robust and effective at placing
models into even challenging cryo-EM maps.

== Keywords ==

== Links ==

https://scripts.iucr.org/cgi-bin/paper?vo5012

== Related software ==

== Related methods ==

== Comments ==

2023Millan LL - Revision history

WikiSysop: Created page with "== Citation == Millán, Claudia / McCoy, Airlie J. / Terwilliger, Thomas C. / Read, Randy J. Likelihood-based docking of models into cryo-EM maps. 2023. Acta Crystallographic..."