https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2023Read_LL 2026-05-24T21:06:33Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2023Read_LL&diff=4408&oldid=prev 2023-08-14T06:45:56Z

<p>Created page with &quot;== Citation == Read, Randy J. / Millán, Claudia / McCoy, Airlie J. / Terwilliger, Thomas C. Likelihood-based signal and noise analysis for docking of models into cryo-EM map...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> Read, Randy J. / Millán, Claudia / McCoy, Airlie J. / Terwilliger, Thomas C. Likelihood-based signal and noise analysis for docking of models into cryo-EM maps. 2023. Acta Crystallographica Section D: Structural Biology, Vol. 79, p. 271-280 <br /> <br /> == Abstract ==<br /> <br /> Fast, reliable docking of models into cryo-EM maps requires understanding of<br /> the errors in the maps and the models. Likelihood-based approaches to errors<br /> have proven to be powerful and adaptable in experimental structural biology,<br /> finding applications in both crystallography and cryo-EM. Indeed, previous<br /> crystallographic work on the errors in structural models is directly applicable to<br /> likelihood targets in cryo-EM. Likelihood targets in Fourier space are derived<br /> here to characterize, based on the comparison of half-maps, the direction- and<br /> resolution-dependent variation in the strength of both signal and noise in the<br /> data. Because the signal depends on local features, the signal and noise are<br /> analysed in local regions of the cryo-EM reconstruction. The likelihood analysis<br /> extends to prediction of the signal that will be achieved in any docking<br /> calculation for a model of specified quality and completeness. A related<br /> calculation generalizes a previous measure of the information gained by making<br /> the cryo-EM reconstruction.<br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> https://scripts.iucr.org/cgi-bin/paper?vo5011<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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