https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2023Toader_Heterogeneity 2026-06-13T12:12:34Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2023Toader_Heterogeneity&diff=4420&oldid=prev 2023-08-23T17:05:57Z

<p>Created page with &quot;== Citation == Toader, Bogdan / Sigworth, Fred J. / Lederman, Roy R. Methods for Cryo-EM single particle reconstruction of macromolecules having continuous heterogeneity. 202...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> Toader, Bogdan / Sigworth, Fred J. / Lederman, Roy R. Methods for Cryo-EM single particle reconstruction of macromolecules having continuous heterogeneity. 2023. J. Molecular Biology, Vol. 435, No. 9, p. 168020 <br /> <br /> == Abstract ==<br /> <br /> Macromolecules change their shape (conformation) in the process of carrying out their functions. The<br /> imaging by cryo-electron microscopy of rapidly-frozen, individual copies of macromolecules (single particles)<br /> is a powerful and general approach to understanding the motions and energy landscapes of macromolecules.<br /> Widely-used computational methods already allow the recovery of a few distinct conformations<br /> from heterogeneous single-particle samples, but the treatment of complex forms of heterogeneity such as<br /> the continuum of possible transitory states and flexible regions remains largely an open problem. In recent<br /> years there has been a surge of new approaches for treating the more general problem of continuous<br /> heterogeneity. This paper surveys the current state of the art in this area.<br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> https://www.sciencedirect.com/science/article/pii/S0022283623000761<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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