https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2024Lander_Validation2024Lander Validation - Revision history2026-05-24T21:06:00ZRevision history for this page on the wikiMediaWiki 1.44.2https://3demmethods.i2pc.es/index.php?title=2024Lander_Validation&diff=4791&oldid=prevWikiSysop: Created page with "== Citation == G. C. Lander, “Single particle cryo-EM map and model validation: It’s not crystal clear,” Current Opinion in Structural Biology, vol. 89, p. 102918, 2024. == Abstract == The application of single particle cryogenic electron microscopy (cryo-EM) to structure determination continues to have a transformative impact on our understanding on biological systems. While there has been a great deal of algorithmic development focused on improving attainable..."2024-10-22T14:48:56Z<p>Created page with "== Citation == G. C. Lander, “Single particle cryo-EM map and model validation: It’s not crystal clear,” Current Opinion in Structural Biology, vol. 89, p. 102918, 2024. == Abstract == The application of single particle cryogenic electron microscopy (cryo-EM) to structure determination continues to have a transformative impact on our understanding on biological systems. While there has been a great deal of algorithmic development focused on improving attainable..."</p>
<p><b>New page</b></p><div>== Citation ==<br />
<br />
G. C. Lander, “Single particle cryo-EM map and model validation: It’s not crystal clear,” Current Opinion in Structural Biology, vol. 89, p. 102918, 2024.<br />
<br />
== Abstract ==<br />
<br />
The application of single particle cryogenic electron microscopy<br />
(cryo-EM) to structure determination continues to have a<br />
transformative impact on our understanding on biological<br />
systems. While there has been a great deal of algorithmic<br />
development focused on improving attainable resolutions and<br />
streamlining atomic model building, there has not been<br />
commensurate development of validation metrics to ensure the<br />
accuracy of our cryo-EM maps and models. This review emphasizes<br />
the persistent issues that currently complicate single<br />
particle cryo-EM structure validation, and highlights the metrics<br />
that are gaining broad acceptance by the community. This<br />
article aims to underscore the need for further development of<br />
validation criteria and the potential role of machine learning<br />
methodologies in confidently assessing the quality of cryo-EM<br />
structures.<br />
<br />
== Keywords ==<br />
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== Links ==<br />
<br />
https://www.sciencedirect.com/science/article/pii/S0959440X24001453<br />
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== Related software ==<br />
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== Related methods ==<br />
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== Comments ==</div>WikiSysop