WikiSysop: Created page with "== Citation == Muller, Tommi / Duncan, Adriana L. / Verbeke, Eric / Kileel, Joe. Algebraic Constraints and Algorithms for Common Lines in Cryo-EM. 2024. Biological Imaging, p. 1-30 == Abstract == We revisit the topic of common lines between projection images in single particle cryo-electron microscopy (cryo- EM). We derive a novel low-rank constraint on a certain 2nxn matrix storing properly-scaled basis vectors for the common lines between n projection images of one..."

2024-08-08T05:41:00Z

Created page with "== Citation == Muller, Tommi / Duncan, Adriana L. / Verbeke, Eric / Kileel, Joe. Algebraic Constraints and Algorithms for Common Lines in Cryo-EM. 2024. Biological Imaging, p. 1-30 == Abstract == We revisit the topic of common lines between projection images in single particle cryo-electron microscopy (cryo- EM). We derive a novel low-rank constraint on a certain 2nxn matrix storing properly-scaled basis vectors for the common lines between n projection images of one..."

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== Citation ==

Muller, Tommi / Duncan, Adriana L. / Verbeke, Eric / Kileel, Joe. Algebraic Constraints and Algorithms for Common Lines in Cryo-EM. 2024. Biological Imaging, p. 1-30

== Abstract ==

We revisit the topic of common lines between projection images in single particle cryo-electron microscopy (cryo-
EM). We derive a novel low-rank constraint on a certain 2nxn matrix storing properly-scaled basis vectors for
the common lines between n projection images of one molecular conformation. Using this algebraic constraint
and others, we give optimization algorithms to denoise common lines and recover the unknown 3D rotations
associated to the images. As an application, we develop a clustering algorithm to partition a set of noisy images into
homogeneous communities using common lines, in the case of discrete heterogeneity in cryo-EM.We demonstrate
the methods on synthetic and experimental datasets.

== Keywords ==

== Links ==

https://www.cambridge.org/core/journals/biological-imaging/article/algebraic-constraints-and-algorithms-for-common-lines-in-cryoem/E8857389E474D2C87A59C2E9881C679B

== Related software ==

== Related methods ==

== Comments ==

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