https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2024Verbeke_SelfFSC 2026-06-13T12:13:30Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2024Verbeke_SelfFSC&diff=4539&oldid=prev 2024-01-17T09:16:26Z

<p>Created page with &quot;== Citation == Verbeke, E. J. / Gilles, M. A. / Singer, A. Self Fourier shell correlation: properties and application to cryo-ET. 2024. Communications Biology, Vol. 7, p. 101...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> Verbeke, E. J. / Gilles, M. A. / Singer, A. Self Fourier shell correlation: properties and application to cryo-ET. 2024. Communications Biology, Vol. 7, p. 101 <br /> <br /> == Abstract ==<br /> <br /> The Fourier shell correlation (FSC) is a measure of the similarity between two signals<br /> computed over corresponding shells in the frequency domain and has broad applications in<br /> microscopy. In structural biology, the FSC is ubiquitous in methods for validation, resolution<br /> determination, and signal enhancement. Computing the FSC usually requires two independent<br /> measurements of the same underlying signal, which can be limiting for some applications.<br /> Here, we analyze and extend on an approach to estimate the FSC from a single<br /> measurement. In particular, we derive the necessary conditions required to estimate the FSC<br /> from downsampled versions of a single noisy measurement. These conditions reveal additional<br /> corrections which we implement to increase the applicability of the method. We then<br /> illustrate two applications of our approach, first as an estimate of the global resolution from a<br /> single 3-D structure and second as a data-driven method for denoising tomographic<br /> reconstructions in electron cryo-tomography. These results provide general guidelines for<br /> computing the FSC from a single measurement and suggest new applications of the FSC<br /> in microscopy.<br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> https://www.nature.com/articles/s42003-023-05724-y<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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