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	<title>2025Balanov Confirmation - Revision history</title>
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	<updated>2026-04-16T17:23:21Z</updated>
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		<title>WikiSysop: Created page with &quot;== Citation ==  Balanov, A., Bendory, T. and Huleihel, W. 2025. Confirmation bias in Gaussian mixture models. IEEE Trans. on Information Theory. (2025).  == Abstract ==  Confirmation bias, the tendency to interpret information in a way that aligns with one’s preconceptions, can profoundly impact scientific research, leading to conclusions that reflect the researcher’s hypotheses even when the observational data do not support them. This issue is especially critical i...&quot;</title>
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		<updated>2026-02-20T06:35:06Z</updated>

		<summary type="html">&lt;p&gt;Created page with &amp;quot;== Citation ==  Balanov, A., Bendory, T. and Huleihel, W. 2025. Confirmation bias in Gaussian mixture models. IEEE Trans. on Information Theory. (2025).  == Abstract ==  Confirmation bias, the tendency to interpret information in a way that aligns with one’s preconceptions, can profoundly impact scientific research, leading to conclusions that reflect the researcher’s hypotheses even when the observational data do not support them. This issue is especially critical i...&amp;quot;&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;== Citation ==&lt;br /&gt;
&lt;br /&gt;
Balanov, A., Bendory, T. and Huleihel, W. 2025. Confirmation bias in Gaussian mixture models. IEEE Trans. on Information Theory. (2025).&lt;br /&gt;
&lt;br /&gt;
== Abstract ==&lt;br /&gt;
&lt;br /&gt;
Confirmation bias, the tendency to interpret information&lt;br /&gt;
in a way that aligns with one’s preconceptions, can&lt;br /&gt;
profoundly impact scientific research, leading to conclusions that&lt;br /&gt;
reflect the researcher’s hypotheses even when the observational&lt;br /&gt;
data do not support them. This issue is especially critical in&lt;br /&gt;
scientific fields involving highly noisy observations, such as&lt;br /&gt;
cryo-electron microscopy. This study investigates confirmation&lt;br /&gt;
bias in Gaussian mixture models. We consider the following&lt;br /&gt;
experiment: A team of scientists assumes they are analyzing&lt;br /&gt;
data drawn from a Gaussian mixture model with known signals&lt;br /&gt;
(hypotheses) as centroids. However, in reality, the observations&lt;br /&gt;
consist entirely of noise without any informative structure. The&lt;br /&gt;
researchers use a single iteration of the K-means or expectationmaximization&lt;br /&gt;
algorithms, two popular algorithms to estimate the&lt;br /&gt;
centroids. Despite the observations being pure noise, we show that&lt;br /&gt;
these algorithms yield biased estimates that resemble the initial&lt;br /&gt;
hypotheses, contradicting the unbiased expectation that averaging&lt;br /&gt;
these noise observations would converge to zero. Namely, the&lt;br /&gt;
algorithms generate estimates that mirror the postulated model,&lt;br /&gt;
although the hypotheses (the presumed centroids of the Gaussian&lt;br /&gt;
mixture) are not evident in the observations. Specifically,&lt;br /&gt;
among other results, we prove a positive correlation between&lt;br /&gt;
the estimates produced by the algorithms and the corresponding&lt;br /&gt;
hypotheses. We also derive explicit closed-form expressions of&lt;br /&gt;
the estimates for a finite and infinite number of hypotheses.&lt;br /&gt;
Furthermore, we provide theoretical and empirical results for&lt;br /&gt;
multi-iteration K-means and expectation-maximization, showing&lt;br /&gt;
that the bias is persistent even after hundreds of iterations of&lt;br /&gt;
these algorithms. This study underscores the risks of confirmation&lt;br /&gt;
bias in low signal-to-noise environments, provides insights into&lt;br /&gt;
potential pitfalls in scientific methodologies, and highlights the&lt;br /&gt;
importance of prudent data interpretation.&lt;br /&gt;
&lt;br /&gt;
== Keywords ==&lt;br /&gt;
&lt;br /&gt;
== Links ==&lt;br /&gt;
&lt;br /&gt;
https://ieeexplore.ieee.org/abstract/document/11143585/&lt;br /&gt;
&lt;br /&gt;
== Related software ==&lt;br /&gt;
&lt;br /&gt;
== Related methods ==&lt;br /&gt;
&lt;br /&gt;
== Comments ==&lt;/div&gt;</summary>
		<author><name>WikiSysop</name></author>
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