https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2025Patwardhan_Extending 2026-06-13T12:13:02Z Revision history for this page on the wiki MediaWiki 1.44.2 https://3demmethods.i2pc.es/index.php?title=2025Patwardhan_Extending&diff=5011&oldid=prev 2025-06-30T06:59:12Z

<p>Created page with &quot;== Citation == A. Patwardhan, R. Henderson, and C. J. Russo, “Extending the reach of single-particle cryoEM.,” Current Opinion in Structural Biology, p. 103005, 2025. == Abstract == Molecular structure determination using electron cryomicroscopy (cryoEM) is poised in early 2025 to surpass X-ray crystallography as the most used method for experimentally determining new structures. But the technique has not reached the physical limits set by radiation damage and the...&quot;</p> <p><b>New page</b></p><div>== Citation ==<br /> <br /> A. Patwardhan, R. Henderson, and C. J. Russo, “Extending the reach of single-particle cryoEM.,” Current Opinion in Structural Biology, p. 103005, 2025.<br /> <br /> == Abstract ==<br /> <br /> Molecular structure determination using electron cryomicroscopy<br /> (cryoEM) is poised in early 2025 to surpass X-ray<br /> crystallography as the most used method for experimentally<br /> determining new structures. But the technique has not reached<br /> the physical limits set by radiation damage and the signal-tonoise<br /> ratio in individual images of molecules. By examining<br /> these limits and comparing the number and resolution of<br /> structures determined versus molecular weight, we identify<br /> opportunities for extending the application of single-particle<br /> cryoEM. This will help guide technology development to<br /> continue the exponential growth of structural biology.<br /> <br /> == Keywords ==<br /> <br /> == Links ==<br /> <br /> https://www.sciencedirect.com/science/article/pii/S0959440X25000235<br /> <br /> == Related software ==<br /> <br /> == Related methods ==<br /> <br /> == Comments ==</div>

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