WikiSysop: Created page with "== Citation == Chrencik, J.E., Su, H.-P., Gomez Llorente, Y., Palte, R.L., Klein, D.J., Hayes, R.P., Antine, S.P., Asmar-Rovira, G.A., Bertoletti, N., Byrne, N.J. and others 2026. The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. Biological Crystallography. 82, 6 (2026). == Abstract == Structural biology has fundamentally influenced pharmaceutical research and development at Merck Sharp & Dohm..."

2026-07-07T06:31:08Z

Created page with "== Citation == Chrencik, J.E., Su, H.-P., Gomez Llorente, Y., Palte, R.L., Klein, D.J., Hayes, R.P., Antine, S.P., Asmar-Rovira, G.A., Bertoletti, N., Byrne, N.J. and others 2026. The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. Biological Crystallography. 82, 6 (2026). == Abstract == Structural biology has fundamentally influenced pharmaceutical research and development at Merck Sharp & Dohm..."

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== Citation ==

Chrencik, J.E., Su, H.-P., Gomez Llorente, Y., Palte, R.L., Klein, D.J., Hayes, R.P., Antine, S.P., Asmar-Rovira, G.A., Bertoletti, N., Byrne, N.J. and others 2026. The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. Biological Crystallography. 82, 6 (2026).

== Abstract ==

Structural biology has fundamentally influenced pharmaceutical research and
development at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA,
progressing from pioneering macromolecular crystallography in the 1980s to a
fully integrated platform that today encompasses X-ray crystallography, cryoelectron
microscopy, micro-electron diffraction and cryo-electron tomography.
In this review, we present a comprehensive overview of how these complementary
methods have advanced drug discovery across diverse therapeutic
areas. We illustrate how atomic to cellular structural insights inform drug
discovery and development, from target identification and validation, hit
finding, lead identification through lead optimization and clinical progression.
Furthermore, we describe how structural biology techniques aid in formulation
strategies of antibodies and vaccines. Finally, we highlight the growing integration
of ex situ and in situ approaches as a paradigm shift towards elucidating
drug mechanisms in native cellular contexts, a transition poised to accelerate the
discovery and development of next-generation therapeutics.

== Keywords ==

== Links ==

https://journals.iucr.org/d/issues/2026/06/00/raj5002/index.html

== Related software ==

== Related methods ==

== Comments ==

2026Chrencik SBDD - Revision history