WikiSysop: Created page with "== Citation == Lin, X. and Cheng, Y. 2026. Making sense of invisible densities in single-particle cryo-EM. IUCrJ. 13, 3 (2026). == Abstract == In the era of single-particle cryogenic electron microscopy (cryo-EM) and AIdriven protein structure prediction, obtaining high-resolution protein structures, either experimentally or computationally, has become increasingly routine. Yet studying and understanding protein dynamics remains challenging. In singleparticle cryo-EM,..."

2026-04-30T05:51:34Z

Created page with "== Citation == Lin, X. and Cheng, Y. 2026. Making sense of invisible densities in single-particle cryo-EM. IUCrJ. 13, 3 (2026). == Abstract == In the era of single-particle cryogenic electron microscopy (cryo-EM) and AIdriven protein structure prediction, obtaining high-resolution protein structures, either experimentally or computationally, has become increasingly routine. Yet studying and understanding protein dynamics remains challenging. In singleparticle cryo-EM,..."

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== Citation ==

Lin, X. and Cheng, Y. 2026. Making sense of invisible densities in single-particle cryo-EM. IUCrJ. 13, 3 (2026).

== Abstract ==

In the era of single-particle cryogenic electron microscopy (cryo-EM) and AIdriven
protein structure prediction, obtaining high-resolution protein structures,
either experimentally or computationally, has become increasingly routine. Yet
studying and understanding protein dynamics remains challenging. In singleparticle
cryo-EM, protein dynamics are most obviously manifested as poor local
resolution or disappearing densities in specific regions of a reconstruction. No
method is yet available to computationally generate conformational ensembles
that fully deconvolute these experimental observations. When dynamics are key
to understanding protein function, it is clear to us that introducing new
experimental approaches is necessary to close this gap and make sense of
invisible densities in single-particle cryo-EM.

== Keywords ==

== Links ==

https://journals.iucr.org/m/issues/2026/03/00/jt5084/index.html

== Related software ==

== Related methods ==

== Comments ==

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