https://3demmethods.i2pc.es/index.php?action=history&feed=atom&title=2026Savas_Distogram2026Savas Distogram - Revision history2026-08-13T18:45:21ZRevision history for this page on the wikiMediaWiki 1.44.2https://3demmethods.i2pc.es/index.php?title=2026Savas_Distogram&diff=5255&oldid=prevWikiSysop: Created page with "== Citation == Savaş, B., Barlas, A.B. and Karaca, E. 2026. Exploring the potential of AlphaFold distograms for predicting binding-induced hinge motions. FEBS letters. 600, 10 (2026), 1558–1570. == Abstract == AlphaFold models provide static structural predictions, limiting their use in interpreting flexible regions in low-resolution cryo-EM maps. Here, we assess whether AlphaFold-generated distograms can instead reveal conformational flexibility, focusing on bindi..."2026-08-13T06:32:42Z<p>Created page with "== Citation == Savaş, B., Barlas, A.B. and Karaca, E. 2026. Exploring the potential of AlphaFold distograms for predicting binding-induced hinge motions. FEBS letters. 600, 10 (2026), 1558–1570. == Abstract == AlphaFold models provide static structural predictions, limiting their use in interpreting flexible regions in low-resolution cryo-EM maps. Here, we assess whether AlphaFold-generated distograms can instead reveal conformational flexibility, focusing on bindi..."</p>
<p><b>New page</b></p><div>== Citation ==<br />
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Savaş, B., Barlas, A.B. and Karaca, E. 2026. Exploring the potential of AlphaFold distograms for predicting binding-induced hinge motions. FEBS letters. 600, 10 (2026), 1558–1570.<br />
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== Abstract ==<br />
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AlphaFold models provide static structural predictions, limiting their use in interpreting flexible regions in low-resolution cryo-EM maps. Here, we assess whether AlphaFold-generated distograms can instead reveal conformational flexibility, focusing on binding-induced hinge motions. For this, we examined the key metabolic AK2/AIFM1 complex, where molecular dynamics and cryo-EM confirm a hinge motion in AK2 upon binding. Notably, this motion is captured in the AlphaFold2/3 distograms of apo AK2, even though it is absent in the predicted structures. By extending our analysis to other systems, we demonstrate that distograms may offer a valuable, model-independent method for interpreting ambiguous hinge regions in cryo-EM maps.<br />
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== Links ==<br />
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https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.70297<br />
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== Comments ==</div>WikiSysop