2007Sorzano Review: Difference between revisions
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C.O.S. Sorzano, S. Jonic, M. Cottevieille, E. Larquet, N. Boisset, S. Marco. 3D Electron microscopy of biological nanomachines: principles and applications. European Biophysics Journal, 36: 995-1013 (2007) | |||
[http://scholar.google.com/scholar?hl=en&lr=&newwindow=1&cites=4528018527944230035 Cited by] | [http://scholar.google.com/scholar?hl=en&lr=&newwindow=1&cites=4528018527944230035 Cited by] | ||
Latest revision as of 09:25, 2 April 2009
Citation
C.O.S. Sorzano, S. Jonic, M. Cottevieille, E. Larquet, N. Boisset, S. Marco. 3D Electron microscopy of biological nanomachines: principles and applications. European Biophysics Journal, 36: 995-1013 (2007)
Abstract
Transmission electron microscopy is a powerful technique for studying the three-dimensional (3D) structure of a wide range of biological specimens. Knowledge of this structure is crucial for fully understanding complex relationships among macromolecular complexes and organelles in living cells. In this paper, we present the principles and main application domains of 3D transmission electron microscopy in structural biology. Moreover, we survey current developments needed in this field, and discuss the close relationship of 3D transmission electron microscopy with other experimental techniques aimed at obtaining structural and dynamical information from the scale of whole living cells to atomic structure of macromolecular complexes.
Keywords
Review, image processing techniques
Links
Article http://www.ncbi.nlm.nih.gov/pubmed/17611751