2003Lee Review

Citation

Lee KK, Johnson JE (2003) Complementary approaches to structure determination of icosahedral viruses. Curr Opin Struct Biol 13:558–569

Cited by

Abstract

Few biological macromolecular complexes exhibit the combination of massive size and hierarchical, symmetrical architecture embodied in icosahedral viruses. X-ray crystallography, electron cryomicroscopy and small-angle X-ray scattering provide complementary approaches to studying these remarkable structures. Through a combined approach, progress has been made towards providing detailed structures of highly complex and very large viruses, and towards imaging the dynamic structural changes performed by viruses at key stages in their life cycles.

Keywords

Icosahedral particles, review

Links

Article http://www.ncbi.nlm.nih.gov/pubmed/14568610