Koster AJ, Klumperman J (2003) Electron microscopy in cell biology: integrating structure and function. Nat Cell Biol Suppl S:SS6– SS10
Electron microscopy (EM) is at the highest-resolution limit of a spectrum of complementary morphological techniques. When combined with molecular detection methods, EM is the only technique with sufficient resolution to localize proteins to small membrane subdomains in the context of the cell. Recent procedural and technical developments have increasingly improved the power of EM as a cell-biological tool.
Review, electron tomography