Ourmazd, Abbas / Moffat, Keith / Lattman, Eaton Edward. Structural biology is solved - now what? 2022-01, Nature methods, Vol. 19, p. 24-26
The splendid computational success of AlphaFold and RoseTTAFold in solving the 60-year-old problem of protein
folding raises an obvious question: what new avenues should structural biology explore? We propose a strong pivot
toward the goal of reading mechanism and function directly from the amino acid sequence. This ambitious goal will
require new data analytical tools and an extensive database of the atomic-level structural trajectories traced out on
energy landscapes as proteins perform their function.