Difference between revisions of "2021Sorzano PCA"
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Latest revision as of 10:59, 26 May 2021
Citation
Sorzano, C. O. S. & Carazo, J. M. Principal component analysis is limited to low-resolution analysis in cryoEM. Acta Crystallographica Section D, 2021, 77
Abstract
Principal component analysis (PCA) has been widely proposed to analyze flexibility and heterogeneity in cryo-electron microscopy (cryoEM). In this paper, it is argued that (i) PCA is an excellent technique to describe continuous flexibility at low resolution (but not so much at high resolution) and (ii) PCA components should be analyzed in a concerted manner (and not independently).
Keywords
Links
https://scripts.iucr.org/cgi-bin/paper?S2059798321002291
