2025Farheen Modeling

Citation

F. Farheen, G. Terashi, H. Zhu, and D. Kihara, “AI-based methods for biomolecular structure modeling for Cryo-EM,” Current Opinion in Structural Biology, vol. 90, p. 102989, 2025.

Abstract

Cryo-electronmicroscopy (Cryo-EM) has revolutionized structural biology by enabling the determination of macromolecular structures that were challenging to study with conventional methods. Processing cryo-EM data involves several computational steps to derive three-dimensional structures from raw projections. Recent advancements in artificial intelligence (AI) including deep learning have significantly improved the performance of these processes. In this review, we discuss state-of-the-art AI-based techniques used in key steps of cryo-EM data processing, including macromolecular structure modeling and heterogeneity analysis.

Links

https://www.sciencedirect.com/science/article/pii/S0959440X25000077