2026Evans Counting

Citation

Evans, L., Dingeldein, L., Covino, R., Gilles, M.A., Thiede, E. and Cossio, P. 2026. Counting particles in cryo-electron microscopy may result in incorrect population estimates. Communications Biology. 9, 1 (2026), 421.

Abstract

Counting particles is a common practice in estimating populations from cryo-electron microscopy data. Here, it is shown that counting particles is not robust to noise, whereas statistically rigorous population-estimation methods are more resilient and hold promise for future development.

Links

https://www.nature.com/articles/s42003-026-09859-6