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• 06:44, 4 February 2025 WikiSysop talk contribs created page 2024Kimanius Blush (Created page with "== Citation == D. Kimanius et al., “Data-driven regularization lowers the size barrier of cryo-EM structure determination,” Nature Methods, pp. 1–6, 2024. == Abstract == Macromolecular structure determination by electron cryo-microscopy (cryo-EM) is limited by the alignment of noisy images of individual particles. Because smaller particles have weaker signals, alignment errors impose size limitations on its applicability. Here, we explore how image alignment is...")