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A user with 2,400 edits. Account created on 30 March 2009.
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31 July 2024

  • 06:2806:28, 31 July 2024 diff hist +80 Main Page →CTF estimation and restoration
  • 06:2306:23, 31 July 2024 diff hist +928 N 2024Riggi Animation Created page with "== Citation == Riggi, Margot / Torrez, Rachel M. / Iwasa, Janet H. 3D animation as a tool for integrative modeling of dynamic molecular mechanisms. 2024. Structure, Vol. 32, No. 2, p. 122-130 == Abstract == As the scientific community accumulates diverse data describing how molecular mechanisms occur, creating and sharing visual models that integrate the richness of this information has become increasingly important to help us explore, refine, and communicate our hypo..." current
  • 06:2306:23, 31 July 2024 diff hist +98 Main Page →Books and reviews
  • 06:1106:11, 31 July 2024 diff hist +1,648 N 2024Feng DeepQs Created page with "== Citation == Feng, Ming-Feng / Chen, Yu-Xuan / Shen, Hong-Bin. DeepQs: Local quality assessment of cryo-EM density map by deep learning map-model fit score. 2024. J. Structural Biology, Vol. 216, No. 1, p. 108059 == Abstract == Cryogenic electron microscopy maps are valuable for determining macromolecule structures. A proper quality assessment method is essential for cryo-EM map selection or revision. This article presents DeepQs, a novel approach to estimate local..." current
  • 06:1006:10, 31 July 2024 diff hist +69 Main Page →Validation
  • 06:0106:01, 31 July 2024 diff hist +1,453 N 2023Sweeney ChemEM Created page with "== Citation == Sweeney, Aaron / Mulvaney, Thomas / Maiorca, Mauro / Topf, Maya. ChemEM: Flexible Docking of Small Molecules in Cryo-EM Structures. 2023. J. Medicinal Chemistry, Vol. 67, No. 1, p. 199-212 == Abstract == Cryo-electron microscopy (cryo-EM), through resolution advancements, has become pivotal in structure-based drug discovery. However, most cryo-EM structures are solved at 3−4 Å resolution, posing challenges for small-molecule docking and structure-bas..." current
  • 06:0006:00, 31 July 2024 diff hist +107 Main Page →Fitting and docking
  • 05:5405:54, 31 July 2024 diff hist +1,597 N 2024Yoshidome 4D Created page with "== Citation == Yoshidome, Takashi. Four-dimensional imaging for cryo-electron microscopy experiments using molecular simulations and manifold learning. 2024. J. Computational Chemistry, Vol. 45, No. 11, p. 738-751 == Abstract == Elucidating protein conformational changes is essential because conformational changes are closely related to the functions of proteins. Cryo-electron microscopy (cryo-EM) experiment can be used to reconstruct protein conformational changes vi..." current
  • 05:5305:53, 31 July 2024 diff hist +86 Main Page →3D Heterogeneity
  • 05:4405:44, 31 July 2024 diff hist +1,524 N 2023Fernandez Local Created page with "== Citation == Fernandez-Gimenez, Estrella / Carazo, J. M. / Sorzano, C. O. S. Local defocus estimation in single particle analysis in cryo-electron microscopy. 2023. J. Structural Biology, Vol. 215, No. 4, p. 108030 == Abstract == Single Particle analysis (SPA) aims to determine the three-dimensional structure of proteins and macromolecular complexes. The current state of the art has allowed us to achieve near-atomic and even atomic resolutions. To obtain high-resolu..." current
  • 05:4305:43, 31 July 2024 diff hist +66 Main Page →CTF estimation and restoration

30 July 2024

  • 06:1506:15, 30 July 2024 diff hist +1,751 N 2024deIsidro deep Created page with "== Citation == de Isidro-Gómez, Federico P. / Vilas, J. L. / Losana, P. / Carazo, J. M. / Sorzano, Carlos Oscar Sanchez. A deep learning approach to the automatic detection of alignment errors in cryo-electron tomographic reconstructions. 2024. J. Structural Biology, Vol. 216, No. 1, p. 108056 == Abstract == Electron tomography is an imaging technique that allows for the elucidation of three-dimensional structural information of biological specimens in a very general..." current
  • 06:1506:15, 30 July 2024 diff hist +130 Main Page →Image alignment
  • 06:0106:01, 30 July 2024 diff hist +1,415 N 2023Zhu CryoSieve Created page with "== Citation == Zhu, Jianying / Zhang, Qi / Zhang, Hui / Shi, Zuoqiang / Hu, Mingxu / Bao, Chenglong. A minority of final stacks yields superior amplitude in single-particle cryo-EM. 2023. Nature Communications, Vol. 14, No. 1, p. 7822 == Abstract == Cryogenic electron microscopy (cryo-EM) is widely used to determine nearatomic resolution structures of biological macromolecules. Due to the low signal-to-noise ratio, cryo-EM relies on averaging many images. However, a c..." current
  • 06:0006:00, 30 July 2024 diff hist +97 Main Page →3D Reconstruction
  • 05:4805:48, 30 July 2024 diff hist +2,091 N 2022Kimanius Sparse Created page with "== Citation == Kimanius, Dari / Jamali, Kiarash / Scheres, Sjors. Sparse Fourier backpropagation in cryo-EM reconstruction. 2022. Advances in Neural Information Processing Systems, Vol. 35 p. 12395-12408 == Abstract == Electron cryo-microscopy (cryo-EM) is a powerful method for investigating the structures of protein molecules, with important implications for understanding the molecular processes of life and drug development. In this technique, many noisy, two-dimensi..." current
  • 05:4705:47, 30 July 2024 diff hist +77 Main Page →3D Reconstruction

29 July 2024

  • 05:4005:40, 29 July 2024 diff hist +1,527 N 2023Mendez Pipelines Created page with "== Citation == Mendez, Joshua H. / Chua, Eugene Y. D. / Paraan, Mohammadreza / Potter, Clinton S. / Carragher, Bridget. Automated pipelines for rapid evaluation during cryoEM data acquisition 2023. Current Opinion in Structural Biology, Vol. 83, p. 102729 == Abstract == Cryo-electron microscopy (cryoEM) has become a popular method for determining high-resolution structures of biomolecules. However, data processing can be time-consuming, particularly for new researcher..." current
  • 05:3905:39, 29 July 2024 diff hist +88 Main Page →Automated data collection

16 July 2024

  • 07:3007:30, 16 July 2024 diff hist +1,718 N 2024Parkhurst IceSimulation Created page with "== Citation == Parkhurst, James M. / Cavalleri, Anna / Dumoux, Maud / Basham, Mark / Clare, Daniel / Siebert, C. Alistair / Evans, Gwyndaf / Naismith, James H. / Kirkland, Angus / Essex, Jonathan W. Computational models of amorphous ice for accurate simulation of cryo-EM images of biological samples. 2024. Ultramicroscopy, Vol. 256, p. 113882 == Abstract == Simulations of cryo-electron microscopy (cryo-EM) images of biological samples can be used to produce test datas..." current
  • 07:2907:29, 16 July 2024 diff hist +127 Main Page →Image formation
  • 06:5306:53, 16 July 2024 diff hist +1,879 N 2021Himes Simulation Created page with "== Citation == Himes, Benjamin / Grigorieff, Nikolaus. Cryo-TEM simulations of amorphous radiation-sensitive samples using multislice wave propagation. 2021. IUCrJ, Vol. 8, No. 6, p. 943-953 == Abstract == Image simulation plays a central role in the development and practice of highresolution electron microscopy, including transmission electron microscopy of frozen-hydrated specimens (cryo-EM). Simulating images with contrast that matches the contrast observed in expe..." current
  • 06:5206:52, 16 July 2024 diff hist +114 Main Page →Image formation

15 July 2024

  • 08:0308:03, 15 July 2024 diff hist +1,915 N 2023Richardson Overfitting Created page with "== Citation == Richardson, Jane S. / Williams, Christopher J. / Chen, Vincent B. / Prisant, Michael G. / Richardson, David C. The bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions. 2023. Acta Crystallographica Section D: Structural Biology, Vol. 79, No. 12 == Abstract == Model building and refinement, and the validation of their correctness, are very effective and..." current
  • 08:0208:02, 15 July 2024 diff hist +99 Main Page →Fitting and docking
  • 07:4807:48, 15 July 2024 diff hist +1,912 N 2024Yadav Orientation Created page with "== Citation == Yadav, Swati / Vinothkumar, Kutti R. Factors affecting macromolecule orientations in thin films formed in cryo-EM. 2024. Acta Crystallographica Section D: Structural Biology, Vol. 80, No. 7, p. 535-550 == Abstract == The formation of a vitrified thin film embedded with randomly oriented macromolecules is an essential prerequisite for cryogenic sample electron microscopy. Most commonly, this is achieved using the plunge-freeze method first described near..." current
  • 07:4607:46, 15 July 2024 diff hist +98 Main Page →Sample preparation
  • 07:4007:40, 15 July 2024 diff hist +1,632 N 2024Hou Marker Created page with "== Citation == Hou, Gaoxin / Yang, Zhidong / Zang, Dawei / Fernández, Jose-Jesus / Zhang, Fa / Han, Renmin. MarkerDetector: A method for robust fiducial marker detection in electron micrographs using wavelet-based template. 2024. Journal of Structural Biology, Vol. 216, No. 1, p. 108044 == Abstract == Fiducial marker detection in electron micrographs becomes an important and challenging task with the development of large-field electron microscopy. The fiducial marker..." current
  • 07:3907:39, 15 July 2024 diff hist +68 Main Page →Image alignment
  • 07:2907:29, 15 July 2024 diff hist +1,502 N 2024Dickerson magnification Created page with "== Citation == Dickerson, Joshua L. / Leahy, Erin / Peet, Mathew J. / Naydenova, Katerina / Russo, Christopher J. Accurate magnification determination for cryoEM using gold. 2024. Ultramicroscopy , Vol. 256, p. 113883 == Abstract == Determining the correct magnified pixel size of single-particle cryoEM micrographs is necessary to maximize resolution and enable accurate model building. Here we describe a simple and rapid procedure for determining the absolute magnifica..." current
  • 07:2807:28, 15 July 2024 diff hist +100 Main Page →Image formation

12 July 2024

  • 06:1506:15, 12 July 2024 diff hist +1,547 N 2024Gao DomainFit Created page with "== Citation == Gao, Jerry / Tong, Maxwell / Lee, Chinkyu / Gaertig, Jacek / Legal, Thibault / Bui, Khanh Huy. DomainFit: Identification of protein domains in cryo-EM maps at intermediate resolution using AlphaFold2-predicted models. 2024. Structure, Vol. 32, p. 1-12 == Abstract == Cryoelectron microscopy (cryo-EM) has revolutionized the structural determination of macromolecular complexes. With the paradigm shift to structure determination of highly complex endogenous..." current
  • 06:1406:14, 12 July 2024 diff hist +127 Main Page →Segmentation
  • 06:0506:05, 12 July 2024 diff hist +1,556 N 2023Li Classification Created page with "== Citation == Li, Daoyi / Jiang, Wen. Classification of helical polymers with deep-learning language models. 2023. J. Structural Biology, Vol. 215, No. 4, p. 108041 == Abstract == Many macromolecules in biological systems exist in the form of helical polymers. However, the inherent polymorphism and heterogeneity of samples complicate the reconstruction of helical polymers from cryo-EM images. Currently, available 2D classification methods are effective at separating..." current
  • 06:0406:04, 12 July 2024 diff hist +101 Main Page →Filament picking
  • 05:4705:47, 12 July 2024 diff hist +1,671 N 2023Terwilliger AlphaFold Created page with "== Citation == Terwilliger, Thomas C. / Liebschner, Dorothee / Croll, Tristan I. / Williams, Christopher J. / McCoy, Airlie J. / Poon, Billy K. / Afonine, Pavel V. / Oeffner, Robert D. / Richardson, Jane S. / Read, Randy J. / others. AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination. 2024. Nature Methods, Vol. 21, No. 1, p. 110-116 == Abstract == Artificial intelligence-based protein structure predict..." current
  • 05:4305:43, 12 July 2024 diff hist +117 Main Page →Fitting and docking

11 July 2024

  • 16:2216:22, 11 July 2024 diff hist +1,424 N 2023McMullan 100kV Created page with "== Citation == McMullan, Greg / Naydenova, Katerina / Mihaylov, Daniel / Yamashita, Keitaro / Peet, Mathew J. / Wilson, Hugh / Dickerson, Joshua L. / Chen, Shaoxia / Cannone, Giuseppe / Lee, Yang / others. Structure determination by cryoEM at 100 keV. 2023. Proc. Natl. Acad. Sci. USA , Vol. 120, No. 49, p. e2312905120 == Abstract == Electron cryomicroscopy can, in principle, determine the structures of most biological molecules but is currently limited by access, spec..." current
  • 16:2116:21, 11 July 2024 diff hist +56 Main Page →Image formation
  • 16:1416:14, 11 July 2024 diff hist +2,214 N 2024Herre Capsules Created page with "== Citation == Herre, Carol / Ho, Alex / Eisenbraun, Ben / Vincent, James / Nicholson, Thomas / Boutsioukis, Giorgos / Meyer, Peter A. / Ottaviano, Michelle / Krause, Kurt L. / Key, Jason / Sliz, Piotr. Introduction of the Capsules environment to support further growth of the SBGrid structural biology software collection. 2024-06. Acta crystallographica. Section D, Structural biology, Vol. 80, p. 439-450 == Abstract == The expansive scientific software ecosystem, char..." current
  • 16:1116:11, 11 July 2024 diff hist +103 Main Page →Software

20 June 2024

19 January 2024

17 January 2024

15 January 2024

12 January 2024

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