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  • 06:37, 13 August 2026 WikiSysop talk contribs created page 2025Gyawali Multimodal (Created page with "== Citation == Gyawali, R., Dhakal, A. and Cheng, J. 2025. Multimodal deep learning integration of cryo-EM and AlphaFold3 for high-accuracy protein structure determination. Communications Chemistry. 8, 1 (2025), 320. == Abstract == Cryo-electron microscopy (cryo-EM) is a key technology for determining the structures of proteins, particularly large protein complexes. However, automatically building high-accuracy protein structures from cryo-EM density maps remains a cr...")
  • 06:32, 13 August 2026 WikiSysop talk contribs created page 2026Savas Distogram (Created page with "== Citation == Savaş, B., Barlas, A.B. and Karaca, E. 2026. Exploring the potential of AlphaFold distograms for predicting binding-induced hinge motions. FEBS letters. 600, 10 (2026), 1558–1570. == Abstract == AlphaFold models provide static structural predictions, limiting their use in interpreting flexible regions in low-resolution cryo-EM maps. Here, we assess whether AlphaFold-generated distograms can instead reveal conformational flexibility, focusing on bindi...")
  • 06:25, 13 August 2026 WikiSysop talk contribs created page 2025Alexadrescu Mix (Created page with "== Citation == Alexandrescu, L., Lessin, W. and Lander, G.C. 2025. Mix-it-up’: accessible time-resolved cryo-EM on the millisecond timescale. IUCrJ. 12, 6 (2025), 710–724. == Abstract == Biological reactions often involve macromolecules that undergo substrate-induced conformational changes in under a second, yet capturing these transient states remains challenging. While high-resolution structural techniques such as X-ray crystallography and cryo-electron microsco...")
  • 06:18, 13 August 2026 WikiSysop talk contribs created page 2025Toader SGD (Created page with "== Citation == Toader, B., Brubaker, M.A. and Lederman, R.R. 2025. Efficient high-resolution refinement in cryo-EM with stochastic gradient descent. Acta Crystallographica Sec. D. 81, (2025), 327–343. == Abstract == Electron cryo-microscopy (cryo-EM) is an imaging technique that is widely used in structural biology to determine the three-dimensional structure of biological molecules from noisy two-dimensional projections with unknown orientations. As the typical pip...")
  • 06:11, 13 August 2026 WikiSysop talk contribs created page 2026Balanov Confirmation (Created page with "== Citation == Balanov, A., Huleihel, W. and Bendory, T. 2026. Einstein from noise: Statistical analysis. IEEE Transactions on Signal Processing. 74, (2026), 1751–1766. == Abstract == “Einstein from noise” (EfN) is a prominent example of the model bias phenomenon, where systematic errors in the statistical model lead to spurious but consistent estimates. In the EfN experiment, one falsely believes that a set of observations contains noisy, shifted copies of a te...")
  • 04:36, 12 August 2026 WikiSysop talk contribs created page 2025Zhang CryoFastAR (Created page with "== Citation == Zhang, J., Zhou, S., Dai, H., Liu, X., Wang, P., Fan, Z., Pei, Y. and Yu, J. 2025. CryoFastAR: Fast Cryo-EM Ab Initio Reconstruction Made Easy. 2025 IEEE/CVF International Conference on Computer Vision (ICCV) (2025), 8462–8471. == Abstract == Pose estimation from unordered images is fundamental for 3D reconstruction, robotics, and scientific imaging. Recent geometric foundation models, such as DUSt3R, enable end-to-end dense 3D reconstruction but rema...")
  • 04:19, 12 August 2026 WikiSysop talk contribs created page 2026Balanov Einstein (Created page with "== Citation == Balanov, A., Huleihel, W. and Bendory, T. 2026. Einstein from noise: Statistical analysis. IEEE Transactions on Signal Processing. 74, (2026), 1751–1766. == Abstract == “Einstein from noise” (EfN) is a prominent example of the model bias phenomenon, where systematic errors in the statistical model lead to spurious but consistent estimates. In the EfN experiment, one falsely believes that a set of observations contains noisy, shifted copies of a te...")
  • 05:28, 11 August 2026 WikiSysop talk contribs created page 2026Fromm LowDose (Created page with "== Citation == Fromm, S.A. and Mattei, S. 2026. LowDoseWizard–rapid and standardised setup of low-dose cryo-TEM imaging in SerialEM. Acta Crystallographica Sec. D. 82, (2026), 990–997. == Abstract == Structure elucidation of biological macromolecules by single-particle cryogenic electron microscopy (SPA cryo-EM) or cryogenic electron tomography (cryo- ET) relies on low-dose imaging on cryogenic transmission electron microscopes (cryo-TEMs). Routine microscope setu...")
  • 05:13, 10 August 2026 WikiSysop talk contribs created page 2026Marchan Unattended (Created page with "== Citation == Marchán Torres, D., Conesa, P., Garcia, A., Iceta, M., Broche, L., Gragera, M., Linares, R., Kwong, H.S., Chichón, F.J., Svensson, O. and others 2026. An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM. Acta Crystallographica Sec. D. 82, 8 (2026). == Abstract == Single-particle analysis (SPA) by cryogenic electron microscopy (cryo-EM) has become a cornerstone of structural biology; yet, the workflow...")
  • 11:08, 7 August 2026 WikiSysop talk contribs created page 2026Van Polar (Created page with "== Citation == Van, C.T., Reboul, C.F., Caesar, J.J., Meana-Pañeda, R. and Elmlund, H. 2026. A polar Fourier geometric approach to volume-free single-particle 3D reconstruction. IUCrJ. 13, 4 (2026). == Abstract == We introduce a compact mathematical formulation for the inverse singleparticle 3D reconstruction problem, a high-dimensional inverse problem in which millions of parameters are estimated from extremely noisy experimental measurements. Given a collection of...")
  • 06:31, 23 July 2026 WikiSysop talk contribs created page 2013Ruskin DQE (Created page with "== Citation == Ruskin, A.I., Yu, Z. and Grigorieff, N. 2013. Quantitative characterization of electron detectors for transmission electron microscopy. J. Structural biology. 184, 3 (2013), 385–393. == Abstract == A new generation of direct electron detectors for transmission electron microscopy (TEM) promises significant improvement over previous detectors in terms of their modulation transfer function (MTF) and detective quantum efficiency (DQE). However, the perfo...")
  • 06:19, 23 July 2026 WikiSysop talk contribs created page 2026Motta Dublins (Created page with "== Citation == Motta Alves, G., Andrews, T., McBean, P., Wells, T., El-Gomati, M.M., Burkhalter, S., Schulze-Briese, C., Zambon, P., McMullan, G., Henderson, R. and others 2026. The Dublin lens: a Cc= 1.0 mm objective lens intended for CryoEM at 100 keV. Methods in Microscopy. 3, 1 (2026), 19–25. == Abstract == We have designed, fabricated and tested a lens with a chromatic aberration coefficient (Cc) of 1.0 mm, a 4.0 mm pole-gap and 2.0 mm bore that is wide enough...")
  • 06:46, 22 July 2026 WikiSysop talk contribs created page 2024Wang CryoSeek (Created page with "== Citation == Wang, T., Li, Z., Xu, K., Huang, W., Huang, G., Zhang, Q.C. and Yan, N. 2024. CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy. Proceedings of the National Academy of Sciences. 121, 42 (2024), e2417046121. == Abstract == Structural biology is experiencing a paradigm shift from targeted structural determination to structure-guided discovery of previously uncharacterized bioentities. We employed cryoelectron microscopy (cryo-EM)...")
  • 06:43, 9 July 2026 WikiSysop talk contribs created page 2026Petrov Laser (Created page with "== Citation == Petrov, P.N., Zhang, J.T., Remis, J., Axelrod, J.J., Cheng, H., Cooper, E.S., Hicklin, I.K., Sandhaus, S., Schnurr, C., Glaeser, R.M. and others 2026. Laser phase plate improves structure determination of small proteins by cryo-EM. Science. (2026), eaeh0665. == Abstract == Phase plates can in principle overcome the poor image contrast in electron cryo–microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. How...")
  • 06:24, 9 July 2026 WikiSysop talk contribs created page 2026Subramaniam Review (Created page with "== Citation == Subramaniam, S., Kühlbrandt, W. and Henderson, R. 2026. Cryo-EM: the revolution continues. IUCrJ. 13, 4 (2026). == Abstract == The near-universal adoption of electron cryo-microscopy (cryo-EM) by structural and cell biologists has led to exponential growth of the field, especially over the last two decades, with a doubling in the number of deposited electronmicroscopy density maps every 2.5 years. This exponential growth has changed in recent years to...")
  • 06:31, 7 July 2026 WikiSysop talk contribs created page 2026Chrencik SBDD (Created page with "== Citation == Chrencik, J.E., Su, H.-P., Gomez Llorente, Y., Palte, R.L., Klein, D.J., Hayes, R.P., Antine, S.P., Asmar-Rovira, G.A., Bertoletti, N., Byrne, N.J. and others 2026. The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. Biological Crystallography. 82, 6 (2026). == Abstract == Structural biology has fundamentally influenced pharmaceutical research and development at Merck Sharp & Dohm...")
  • 06:17, 7 July 2026 WikiSysop talk contribs created page 2025Starynska Membrane (Created page with "== Citation == Starynska, A., Cameron, C.J., Sigworth, F.J. and Tagare, H.D. 2026. Automated Membrane Detection and Subtraction for Structure Determination of Membrane Proteins in Cryogenic Electron Microscopy. Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (2026), 6553–6562. == Abstract == High-resolution cryo-electron microscopy (cryo-EM) reconstruction of membrane proteins often requires the bilayer membrane containing the prote...")
  • 05:55, 7 July 2026 WikiSysop talk contribs created page 2026Gao CryoKRAQEN (Created page with "== Citation == Gao, W., Wu, Y. and He, X. 2026. CryoKRAQEN: Kernel-Regularized Annealing for Quantized Embedding Networks in Cryo-EM Heterogeneous Reconstruction. Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (2026), 28298–28307. == Abstract == Heterogeneous reconstruction in cryo-electron microscopy (Cryo-EM) is fundamental for understanding macromolecular structural diversity, yet remains challenging due to extreme noise, contin...")
  • 06:58, 2 June 2026 WikiSysop talk contribs created page 2026Behkamal Secondary (Created page with "== Citation == Behkamal, B., Etemadheravi, M.P., Mahmoodjanloo, A., Mansoori, A., Naghibzadeh, M., Al Nasr, K. and Saberi, M.R. 2026. A Novel Machine-Learning Based Method for Resolving Secondary Structure Topology in Medium-Resolution Cryo-EM Density Maps. Intl. J. of Molecular Sciences. 27, 10 (2026), 4388. == Abstract == Medium-resolution cryo-electron microscopy (cryo-EM) density maps preserve substantial information about protein secondary-structure organization;...")
  • 06:16, 2 June 2026 WikiSysop talk contribs created page 2026Kwon Elastic (Created page with "== Citation == Kwon, M.C. and Abrahams, J.P. 2026. Elastic and Inelastic Interactions of Electrons in Transmission Electron Microscopy. Ultramicroscopy. (2026), 114383. == Abstract == High-energy electrons passing through a sample in a transmission electron microscope carry structural information through their interactions with the sample’s atoms. Elastically scattered electrons, which undergo no significant energy loss, convey spatial details in their scattering an...")
  • 05:54, 26 May 2026 WikiSysop talk contribs created page 2026Obrien CryoJax (Created page with "== Citation == O’Brien, M.J., Silva-Sánchez, D., Woollard, G., Je, K., Hanson, S.M., Needleman, D.J., Cossio, P., Thiede, E.H. and Astore, M.A. 2026. CryoJAX: a cryo-electron microscopy image-simulation library in JAX. Acta Crystallographica Sec. D. 82, 3 (2026). == Abstract == While cryo-electron microscopy (cryo-EM) has come to prominence in the last decade due to its ability to resolve biomolecular complexes at atomic resolution, advancements in experimental and...")
  • 06:06, 25 May 2026 WikiSysop talk contribs created page 2025Evans LowDim (Created page with "== Citation == Evans, L., Murad, O.-V., Dingeldein, L., Cossio, P., Covino, R. and Meila, M. 2025. Cryo-EM images are intrinsically low dimensional. PRX Life. 3, 3 (2025), 33025. == Abstract == Simulation-based inference provides a powerful framework for cryoelectron microscopy, employing neural networks in methods like CryoSBI to infer biomolecular conformations via learned latent representations. This latent space represents a rich opportunity, encoding valuable inf...")
  • 06:32, 22 May 2026 WikiSysop talk contribs created page 2026Silva CryoJax (Created page with "== Citation == Silva-Sánchez, D., Berezuk, A.M., Zhu, X., Thiede, E.H., Lederman, R.R. and Cossio, P. 2026. Cryo-Electron Microscopy Structural Ensemble Optimization Using Individual Particles. J. of Chemical Theory and Computation. (2026). == Abstract == Biomolecules are inherently dynamic, transitioning between various conformational states to execute their biological functions; consequently, characterizing their ensemble distributions (the population of these conf...")
  • 06:52, 13 May 2026 WikiSysop talk contribs created page 2026Premaraj DualJet (Created page with "== Citation == Premaraj, N., Huysmans, P., Ploum, M., Schijns, L., Peters, P.J., López-Iglesias, C., Ravelli, R.B. and Knoops, K. 2026. An experimental platform for exploring dual-jet vitrification mechanisms in cryo-EM sample preparation. Methods in Microscopy. 0 (2026). == Abstract == Jet vitrification harnesses the exceptionally high cooling potential of rapidly moving liquid cryogens to achieve ultrafast sample freezing with superior cooling efficiency. Building...")
  • 05:45, 13 May 2026 WikiSysop talk contribs created page 2026Thibodeaux MR (Created page with "== Citation == Thibodeaux, A., Bu, G., Edwards, L.C. and Rova Danelius, E. 2026. High-throughput automated molecular replacement for small-molecule MicroED data. IUCrJ. 13, 3 (2026). == Abstract == Interest in electron diffraction (ED) for structural characterization of both proteins and small molecules has grown significantly over the last decade. While ab initio phasing methods remain the gold standard for ED data from smallmolecule samples, radiation beam damage du...")
  • 08:36, 4 May 2026 WikiSysop talk contribs created page 2025Hu Denoising (Created page with "== Citation == Hu, B., Zhang, D.-X., Liu, S.-Q., Xie, X.-L., Zhou, X.-H., Li, H.-J., Zheng, Q.-B., Zhang, F., Hou, Z.-G. and Xia, N.-S. 2025. Particle Restoration: A Novel Image Processing Framework for Improving Real Cryo-EM Image Quality in Single Particle Analysis. IEEE Trans. on Computational Biology and Bioinformatics. (2025). == Abstract == Cryo-electron microscopy single particle analysis (cryo-EM SPA) is the most powerful technique for biomacromolecule structu...")
  • 06:51, 30 April 2026 WikiSysop talk contribs created page 2025Costa PERC (Created page with "== Citation == Costa-Gomes, B., Greer, J., Juraschko, N., Parkhurst, J., Mirecka, J., Famili, M., Rangel-Smith, C., Strickson, O., Lowe, A., Basham, M. and others 2025. PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning. Structural Biology and Crystallization Communications. 81, 10 (2025). == Abstract == Ease of access to data, tools and models expedites scientific research. In structural biolo...")
  • 06:42, 30 April 2026 WikiSysop talk contribs created page 2025Giri Sharpening (Created page with "== Citation == Giri, N., Chen, X., Wang, L. and Cheng, J. 2025. A labeled dataset for AI-based cryo-EM map enhancement. Computational and Structural Biotechnology Journal. 27, (2025), 2843–2850. == Abstract == Cryogenic electron microscopy (cryo-EM) has transformed structural biology by enabling near atomic resolution imaging of macromolecular complexes. However, cryo-EM density maps suffer from intrinsic noise arising from structural sources, shot noise, and digita...")
  • 05:51, 30 April 2026 WikiSysop talk contribs created page 2026Lin HDX (Created page with "== Citation == Lin, X. and Cheng, Y. 2026. Making sense of invisible densities in single-particle cryo-EM. IUCrJ. 13, 3 (2026). == Abstract == In the era of single-particle cryogenic electron microscopy (cryo-EM) and AIdriven protein structure prediction, obtaining high-resolution protein structures, either experimentally or computationally, has become increasingly routine. Yet studying and understanding protein dynamics remains challenging. In singleparticle cryo-EM,...")
  • 06:41, 28 April 2026 WikiSysop talk contribs created page 2026Chen MPM (Created page with "== Citation == Chen, J., Leung, V.C., Wang, R., Bubeck, D. and Dragotti, P.L. 2026. Masked Projection Modelling for Sparse-view cryo-EM Reconstruction. ICASSP 2026-2026 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (2026), 11567–11571. == Abstract == Resolving conformational heterogeneity in cryo-electron microscopy (cryo-EM) remains challenging, especially for rare states. Standard reconstruction methods, reliant on abundant simi...")
  • 08:52, 23 April 2026 WikiSysop talk contribs created page 2026Gauvin 200kV (Created page with "== Citation == Gauvin, C.C., Findlay, J.L., Hophan-Nichols, C. and Lawrence, C.M. 2026. A cost-effective 200 kV cryo-EM core facility for high resolution single particle analysis. Methods in Microscopy. (2026). == Abstract == We sought to establish a sustainable 200 kV cryo- EM core facility for the Northern Rocky Mountain region with high resolution single particle capabilities. With modest funding, relative to 300 kV instruemnts, from the NSF, theMurdock Charitable...")
  • 07:07, 23 April 2026 WikiSysop talk contribs created page 2026Eluru MISO (Created page with "== Citation == Eluru, G., De Gieter, S., Schenck, S., Stroobants, A., Shrestha, B., Erbel, P., Brunner, J.D. and Efremov, R.G. 2025. MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony. Nature methods. (2025), 1–11. == Abstract == Single-particle cryogenic electron microscopy (cryo-EM) enables reconstruction of atomic-resolution 3D maps of proteins by visualizing thousands to millions of purified pro...")
  • 12:30, 15 April 2026 WikiSysop talk contribs created page 2022Calcraft SPATilts (Created page with "== Citation == Calcraft, T. and Rosenthal, P.B. 2022. Cryogenic electron microscopy approaches that combine images and tilt series. Microscopy. 71, Supplement_1 (Feb. 2022), i15–i22. == Abstract == Cryogenic electron microscopy can be widely applied to biological specimens from the molecular to the cellular scale. In single-particle analysis, 3D structures may be obtained in high resolution by averaging 2D images of single particles in random orientations. For pleo...")
  • 12:46, 13 April 2026 WikiSysop talk contribs created page 2026Wazny Damage (Created page with "== Citation == Ważny, G., Jaciuk, M., Indyka, P., Glatt, S., Biela, A. and Rawski, M. 2026. Influence of total electron dose on the quality of nucleic acids potential maps in Cryo-EM. Ultramicroscopy. (2026), 114358. == Abstract == The standardization of protocols in science lies at the basis of every experiment. During this process, some crucial questions need to be answered. The quality of results in single particle cryo-Electron Microscopy (cryo-EM) requires optim...")
  • 12:33, 13 April 2026 WikiSysop talk contribs created page 2026Evans Counting (Created page with "== Citation == Evans, L., Dingeldein, L., Covino, R., Gilles, M.A., Thiede, E. and Cossio, P. 2026. Counting particles in cryo-electron microscopy may result in incorrect population estimates. Communications Biology. 9, 1 (2026), 421. == Abstract == Counting particles is a common practice in estimating populations from cryo-electron microscopy data. Here, it is shown that counting particles is not robust to noise, whereas statistically rigorous population-estimation m...")
  • 12:20, 13 April 2026 WikiSysop talk contribs created page 2026He prismPYP (Created page with "== Citation == He, L. and Bartesaghi, A. 2026. prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation. Structure. 34, (2026), 1–12. == Abstract == High-throughput data collection in single-particle cryo-electron microscopy (EM) necessitates fast, accurate, and generalizable methods to assess micrograph quality. Manual micrograph curation scales poorly to large datasets and often misclassifies images due to sample-specific variab...")
  • 12:52, 9 April 2026 WikiSysop talk contribs created page 2026Chen 3DDF-VAE (Created page with "== Citation == Chen, Y., Li, F., Dong, H., Wang, X., Zhang, F., Hu, B. and Wan, X. 2026. 3DDF-VAE: Dual-frequency variational autoencoder with pose-consistency validation for rare cryo-EM conformation discovery. J. Structural Biology. (2026), 108311. == Abstract == Revealing the 3D conformational variability of biomolecules is crucial for understanding their function, while cryo-EM reconstruction of rare states remains difficult due to data imbalance and structural de...")
  • 09:38, 7 April 2026 WikiSysop talk contribs created page User talk:Javier.vargas (Welcome!)
  • 09:38, 7 April 2026 WikiSysop talk contribs created page User:Javier.vargas (Creating user page for new user.)
  • 09:38, 7 April 2026 User account Javier.vargas talk contribs was created by WikiSysop talk contribs and password was sent by email
  • 16:20, 6 April 2026 WikiSysop talk contribs created page 2026Xu MMSE (Created page with "== Citation == Xu, S., Balanov, A., Singer, A. and Bendory, T. 2026. Bayesian perspective for orientation determination in cryo-EM with application to structural heterogeneity analysis. Biological Crystallography. 82, 4 (2026). == Abstract == Accurate orientation estimation is a crucial component of 3D molecular structure reconstruction, both in single-particle cryo-electron microscopy (cryo-EM) and in the increasingly popular field of cryo-electron tomography (cryo-E...")
  • 10:44, 24 March 2026 WikiSysop talk contribs created page 2022Vilas Emerging (Created page with "== Citation == Vilas, J.L., Carazo, J.M. and Sorzano, C.O.S. 2022. Emerging themes in CryoEM─ Single particle analysis image processing. Chemical Reviews. 122, 17 (2022), 13915–13951. == Abstract == Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is an interdisciplinary field that takes advantage of advances in biochemistry, physics, and image processing, among other disciplines. Innovations in these three basic pillars hav...")
  • 06:35, 20 February 2026 WikiSysop talk contribs created page 2025Balanov Confirmation (Created page with "== Citation == Balanov, A., Bendory, T. and Huleihel, W. 2025. Confirmation bias in Gaussian mixture models. IEEE Trans. on Information Theory. (2025). == Abstract == Confirmation bias, the tendency to interpret information in a way that aligns with one’s preconceptions, can profoundly impact scientific research, leading to conclusions that reflect the researcher’s hypotheses even when the observational data do not support them. This issue is especially critical i...")
  • 07:26, 18 February 2026 WikiSysop talk contribs created page 2026Li Atomic (Created page with "== Citation == Li, T. and Huang, S.-Y. 2026. Deep learning–based postprocessing and model building for cryo-electron microscopy maps. Current Opinion in Structural Biology. 96, (2026), 103196. == Abstract == Cryo-electron microscopy (cryo-EM) has emerged as one of the most powerful techniques for determining the structures of biological macromolecules. The ultimate goal of cryo-EM is to determine the atomic structure of target molecules, where map postprocessing and...")
  • 04:51, 17 February 2026 WikiSysop talk contribs created page 2026Chen CryoEvoBuild (Created page with "== Citation == Chen, J., Li, T., He, J. and Huang, S.-Y. 2026. Protein model building for intermediate-resolution cryo-EM maps by integrating evolutionary and experimental information. Structure. 34, (2026), 375–384. == Abstract == Accurate model building in intermediate-resolution cryo-EM maps normally requires flexible fitting of reliable initial structures. However, while deep learning-based methods such as AlphaFold2 can predict highly accurate structures, the p...")
  • 04:38, 17 February 2026 WikiSysop talk contribs created page 2026Urzhumtsev ProjDir (Created page with "== Citation == Urzhumtsev, A.G. 2026. Quantifying distributions of cryo-EM projections. Biological Crystallography. 82, 2 (2026). == Abstract == In cryo-electron microscopy, a set of two-dimensional projections collected from different viewing directions may complicate image processing and subsequent model building if the distribution of these views is non-uniform. View distributions are traditionally represented as color-coded two-dimensional diagrams. However, such...")
  • 04:30, 17 February 2026 WikiSysop talk contribs created page 2026Barchet NonUniform (Created page with "== Citation == Barchet, C., von Loeffelholz, O., Bahena-Ceron, R., Klaholz, B.P. and Urzhumtsev, A.G. 2026. Explicit correction of severely non-uniform distributions of cryo-EM views. Biological Crystallography. 82, 2 (2026). == Abstract == The quality of three-dimensional macromolecular image reconstruction by cryo electron microscopy (cryo-EM) strongly depends on the number and the quality of the respective two-dimensional projections and on their angular distributi...")
  • 09:04, 13 February 2026 WikiSysop talk contribs created page 2025Zhang CryoPROS (Created page with "== Citation == Zhang, H., Zheng, D., Wu, Q., Yan, N., Peng, H., Hu, Q., Peng, Y., Yan, Z., Shi, Z., Bao, C. and others 2025. CryoPROS: Correcting misalignment caused by preferred orientation using AI-generated auxiliary particles. Nature Communications. 16, 1 (2025), 4565. == Abstract == The preferred orientation phenomenon is a common issue in cryo-EM, posing a persistent challenge to conventional reconstruction methods. In this study, we introduce cryoPROS, a comput...")
  • 07:58, 13 February 2026 WikiSysop talk contribs created page 2026Zhou Atomic (Created page with "== Citation == Zhou, X., Xu, X. and Zhang, G. 2026. When cryo-EM modeling meets structure prediction: Structural biology technologies. Nature Structural & Molecular Biology. (2026), 1–3. == Abstract == Accurately interpreting density maps into atomic models is a central yet challenging goal of cryo-EM. Two studies now reveal distinct ways in which protein structure prediction can be incorporated into cryo-EM model building to enable more accurate and robust automate...")
  • 08:59, 12 February 2026 WikiSysop talk contribs created page 2025Mondal EMSequenceFinder (Created page with "== Citation == Mondal, D., Kumar, V., Satler, T., Ramachandran, R., Saltzberg, D., Chemmama, I., Pilla, K.B., Echeverria, I., Webb, B.M., Gupta, M. and others 2025. Recognizing amino acid sidechains in a medium-resolution cryo-electron density map. Protein Science. 34, 8 (2025), e70217. == Abstract == Building an accurate atomic structure model of a protein into a cryo-electron microscopy (cryo-EM) map at worse than 3 Å resolution is difficult. To facilitate this t...")
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