New pages

2 June 2026

• 06:5806:58, 2 June 2026 2026Behkamal Secondary (hist | edit) [2,958 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Behkamal, B., Etemadheravi, M.P., Mahmoodjanloo, A., Mansoori, A., Naghibzadeh, M., Al Nasr, K. and Saberi, M.R. 2026. A Novel Machine-Learning Based Method for Resolving Secondary Structure Topology in Medium-Resolution Cryo-EM Density Maps. Intl. J. of Molecular Sciences. 27, 10 (2026), 4388. == Abstract == Medium-resolution cryo-electron microscopy (cryo-EM) density maps preserve substantial information about protein secondary-structure organization;...")
• 06:1606:16, 2 June 2026 2026Kwon Elastic (hist | edit) [1,218 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Kwon, M.C. and Abrahams, J.P. 2026. Elastic and Inelastic Interactions of Electrons in Transmission Electron Microscopy. Ultramicroscopy. (2026), 114383. == Abstract == High-energy electrons passing through a sample in a transmission electron microscope carry structural information through their interactions with the sample’s atoms. Elastically scattered electrons, which undergo no significant energy loss, convey spatial details in their scattering an...")

26 May 2026

• 05:5405:54, 26 May 2026 2026Obrien CryoJax (hist | edit) [1,640 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == O’Brien, M.J., Silva-Sánchez, D., Woollard, G., Je, K., Hanson, S.M., Needleman, D.J., Cossio, P., Thiede, E.H. and Astore, M.A. 2026. CryoJAX: a cryo-electron microscopy image-simulation library in JAX. Acta Crystallographica Sec. D. 82, 3 (2026). == Abstract == While cryo-electron microscopy (cryo-EM) has come to prominence in the last decade due to its ability to resolve biomolecular complexes at atomic resolution, advancements in experimental and...")

25 May 2026

• 06:0606:06, 25 May 2026 2025Evans LowDim (hist | edit) [1,697 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Evans, L., Murad, O.-V., Dingeldein, L., Cossio, P., Covino, R. and Meila, M. 2025. Cryo-EM images are intrinsically low dimensional. PRX Life. 3, 3 (2025), 33025. == Abstract == Simulation-based inference provides a powerful framework for cryoelectron microscopy, employing neural networks in methods like CryoSBI to infer biomolecular conformations via learned latent representations. This latent space represents a rich opportunity, encoding valuable inf...")

22 May 2026

• 06:3206:32, 22 May 2026 2026Silva CryoJax (hist | edit) [2,278 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Silva-Sánchez, D., Berezuk, A.M., Zhu, X., Thiede, E.H., Lederman, R.R. and Cossio, P. 2026. Cryo-Electron Microscopy Structural Ensemble Optimization Using Individual Particles. J. of Chemical Theory and Computation. (2026). == Abstract == Biomolecules are inherently dynamic, transitioning between various conformational states to execute their biological functions; consequently, characterizing their ensemble distributions (the population of these conf...")

13 May 2026

• 06:5206:52, 13 May 2026 2026Premaraj DualJet (hist | edit) [1,980 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Premaraj, N., Huysmans, P., Ploum, M., Schijns, L., Peters, P.J., López-Iglesias, C., Ravelli, R.B. and Knoops, K. 2026. An experimental platform for exploring dual-jet vitrification mechanisms in cryo-EM sample preparation. Methods in Microscopy. 0 (2026). == Abstract == Jet vitrification harnesses the exceptionally high cooling potential of rapidly moving liquid cryogens to achieve ultrafast sample freezing with superior cooling efficiency. Building...")
• 05:4505:45, 13 May 2026 2026Thibodeaux MR (hist | edit) [1,730 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Thibodeaux, A., Bu, G., Edwards, L.C. and Rova Danelius, E. 2026. High-throughput automated molecular replacement for small-molecule MicroED data. IUCrJ. 13, 3 (2026). == Abstract == Interest in electron diffraction (ED) for structural characterization of both proteins and small molecules has grown significantly over the last decade. While ab initio phasing methods remain the gold standard for ED data from smallmolecule samples, radiation beam damage du...")

4 May 2026

• 08:3608:36, 4 May 2026 2025Hu Denoising (hist | edit) [2,220 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Hu, B., Zhang, D.-X., Liu, S.-Q., Xie, X.-L., Zhou, X.-H., Li, H.-J., Zheng, Q.-B., Zhang, F., Hou, Z.-G. and Xia, N.-S. 2025. Particle Restoration: A Novel Image Processing Framework for Improving Real Cryo-EM Image Quality in Single Particle Analysis. IEEE Trans. on Computational Biology and Bioinformatics. (2025). == Abstract == Cryo-electron microscopy single particle analysis (cryo-EM SPA) is the most powerful technique for biomacromolecule structu...")

30 April 2026

• 06:5106:51, 30 April 2026 2025Costa PERC (hist | edit) [2,456 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Costa-Gomes, B., Greer, J., Juraschko, N., Parkhurst, J., Mirecka, J., Famili, M., Rangel-Smith, C., Strickson, O., Lowe, A., Basham, M. and others 2025. PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning. Structural Biology and Crystallization Communications. 81, 10 (2025). == Abstract == Ease of access to data, tools and models expedites scientific research. In structural biolo...")
• 06:4206:42, 30 April 2026 2025Giri Sharpening (hist | edit) [1,604 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Giri, N., Chen, X., Wang, L. and Cheng, J. 2025. A labeled dataset for AI-based cryo-EM map enhancement. Computational and Structural Biotechnology Journal. 27, (2025), 2843–2850. == Abstract == Cryogenic electron microscopy (cryo-EM) has transformed structural biology by enabling near atomic resolution imaging of macromolecular complexes. However, cryo-EM density maps suffer from intrinsic noise arising from structural sources, shot noise, and digita...")
• 05:5105:51, 30 April 2026 2026Lin HDX (hist | edit) [1,124 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Lin, X. and Cheng, Y. 2026. Making sense of invisible densities in single-particle cryo-EM. IUCrJ. 13, 3 (2026). == Abstract == In the era of single-particle cryogenic electron microscopy (cryo-EM) and AIdriven protein structure prediction, obtaining high-resolution protein structures, either experimentally or computationally, has become increasingly routine. Yet studying and understanding protein dynamics remains challenging. In singleparticle cryo-EM,...")

28 April 2026

• 06:4106:41, 28 April 2026 2026Chen MPM (hist | edit) [1,574 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Chen, J., Leung, V.C., Wang, R., Bubeck, D. and Dragotti, P.L. 2026. Masked Projection Modelling for Sparse-view cryo-EM Reconstruction. ICASSP 2026-2026 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (2026), 11567–11571. == Abstract == Resolving conformational heterogeneity in cryo-electron microscopy (cryo-EM) remains challenging, especially for rare states. Standard reconstruction methods, reliant on abundant simi...")

23 April 2026

• 08:5208:52, 23 April 2026 2026Gauvin 200kV (hist | edit) [1,678 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Gauvin, C.C., Findlay, J.L., Hophan-Nichols, C. and Lawrence, C.M. 2026. A cost-effective 200 kV cryo-EM core facility for high resolution single particle analysis. Methods in Microscopy. (2026). == Abstract == We sought to establish a sustainable 200 kV cryo- EM core facility for the Northern Rocky Mountain region with high resolution single particle capabilities. With modest funding, relative to 300 kV instruemnts, from the NSF, theMurdock Charitable...")
• 07:0707:07, 23 April 2026 2026Eluru MISO (hist | edit) [1,540 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Eluru, G., De Gieter, S., Schenck, S., Stroobants, A., Shrestha, B., Erbel, P., Brunner, J.D. and Efremov, R.G. 2025. MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony. Nature methods. (2025), 1–11. == Abstract == Single-particle cryogenic electron microscopy (cryo-EM) enables reconstruction of atomic-resolution 3D maps of proteins by visualizing thousands to millions of purified pro...")

15 April 2026

• 12:3012:30, 15 April 2026 2022Calcraft SPATilts (hist | edit) [1,677 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Calcraft, T. and Rosenthal, P.B. 2022. Cryogenic electron microscopy approaches that combine images and tilt series. Microscopy. 71, Supplement_1 (Feb. 2022), i15–i22. == Abstract == Cryogenic electron microscopy can be widely applied to biological specimens from the molecular to the cellular scale. In single-particle analysis, 3D structures may be obtained in high resolution by averaging 2D images of single particles in random orientations. For pleo...")

13 April 2026

• 12:4612:46, 13 April 2026 2026Wazny Damage (hist | edit) [1,482 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Ważny, G., Jaciuk, M., Indyka, P., Glatt, S., Biela, A. and Rawski, M. 2026. Influence of total electron dose on the quality of nucleic acids potential maps in Cryo-EM. Ultramicroscopy. (2026), 114358. == Abstract == The standardization of protocols in science lies at the basis of every experiment. During this process, some crucial questions need to be answered. The quality of results in single particle cryo-Electron Microscopy (cryo-EM) requires optim...")
• 12:3312:33, 13 April 2026 2026Evans Counting (hist | edit) [685 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Evans, L., Dingeldein, L., Covino, R., Gilles, M.A., Thiede, E. and Cossio, P. 2026. Counting particles in cryo-electron microscopy may result in incorrect population estimates. Communications Biology. 9, 1 (2026), 421. == Abstract == Counting particles is a common practice in estimating populations from cryo-electron microscopy data. Here, it is shown that counting particles is not robust to noise, whereas statistically rigorous population-estimation m...")
• 12:2012:20, 13 April 2026 2026He prismPYP (hist | edit) [1,590 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == He, L. and Bartesaghi, A. 2026. prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation. Structure. 34, (2026), 1–12. == Abstract == High-throughput data collection in single-particle cryo-electron microscopy (EM) necessitates fast, accurate, and generalizable methods to assess micrograph quality. Manual micrograph curation scales poorly to large datasets and often misclassifies images due to sample-specific variab...")

9 April 2026

• 12:5212:52, 9 April 2026 2026Chen 3DDF-VAE (hist | edit) [1,664 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Chen, Y., Li, F., Dong, H., Wang, X., Zhang, F., Hu, B. and Wan, X. 2026. 3DDF-VAE: Dual-frequency variational autoencoder with pose-consistency validation for rare cryo-EM conformation discovery. J. Structural Biology. (2026), 108311. == Abstract == Revealing the 3D conformational variability of biomolecules is crucial for understanding their function, while cryo-EM reconstruction of rare states remains difficult due to data imbalance and structural de...")

7 April 2026

• 10:0110:01, 7 April 2026 2026Wazny Dose (hist | edit) [1,578 bytes] Javier.vargas (talk | contribs) (Created page with "== Citation == Grzegorz Wazny, Marcin Jaciuk, Paulina Indyka, Sebastian Glatt, Artur Biela, MichaÅ‚ Rawski. Influence of total electron dose on the quality of nucleic acids potential maps in Cryo-EM. Ultramicroscopy, 2026, 283 == Abstract == The standardization of protocols in science lies at the basis of every experiment. During this process, some crucial questions need to be answered. The quality of results in single particle cryo-Electron Microscopy (cryo-EM) r...")

6 April 2026

• 16:2016:20, 6 April 2026 2026Xu MMSE (hist | edit) [2,215 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Xu, S., Balanov, A., Singer, A. and Bendory, T. 2026. Bayesian perspective for orientation determination in cryo-EM with application to structural heterogeneity analysis. Biological Crystallography. 82, 4 (2026). == Abstract == Accurate orientation estimation is a crucial component of 3D molecular structure reconstruction, both in single-particle cryo-electron microscopy (cryo-EM) and in the increasingly popular field of cryo-electron tomography (cryo-E...")

24 March 2026

• 10:4410:44, 24 March 2026 2022Vilas Emerging (hist | edit) [1,221 bytes] WikiSysop (talk | contribs) (Created page with "== Citation == Vilas, J.L., Carazo, J.M. and Sorzano, C.O.S. 2022. Emerging themes in CryoEM─ Single particle analysis image processing. Chemical Reviews. 122, 17 (2022), 13915–13951. == Abstract == Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is an interdisciplinary field that takes advantage of advances in biochemistry, physics, and image processing, among other disciplines. Innovations in these three basic pillars hav...")

4 March 2026

• 10:3910:39, 4 March 2026 2026Xu MarkerFree (hist | edit) [1,397 bytes] Vilas (talk | contribs) (Created page with "== Citation == Z. Xu, Z. Liu, T. Niu, B. He, F. Zhang, X. Li, R. Han, Markerfree: GPU-accelerated marker-free alignment for improved cryo-ET reconstruction, Structure, 0969-2126, (2026) == Abstract == Tilt series alignment is pivotal for cryo-electron tomography (cryo-ET). However, the increasing diversity of cryo-ET datasets, combined with challenges such as low signal-to-noise ratios and complex cellular structures, has significantly raised the demands for tilt se...")