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Show new changes starting from 22:59, 20 February 2026
 
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20 February 2026

N    13:17  2026Liu nextPYP diffhist +2,111 Vilas talk contribs (Created page with "== Citation == HF. Liu, Y. Zhou, Q. Huang, et al. In situ structure determination of conformationally flexible targets using nextPYP. Nat Protoc 21, 851–871 (2026). == Abstract == Single-particle cryoelectron tomography (SP-CET) is an imaging technique capable of determining the structure of proteins in their cellular environment at high-resolution. nextPYP is a web-based application designed to streamline the SP-CET structure determination process and facilitate t...")
N    12:58  2026Schreiber Turonova TANGO diffhist +1,538 Vilas talk contribs (Created page with "== Citation == M. Schreiber, B. Turoňová, TANGO: Analysis and curation of particles in cryo-electron tomography. Nat Commun 17, 1557 (2026). == Abstract == Cryo-electron tomography (cryo-ET) enables the visualization of cellular structures in near-native environments, but its potential for spatial analysis has been underutilized due to a lack of versatile tools accommodating biological sample diversity. Available solutions often rely on case-specific or hypothesis...")
N    12:43  2026JCarrion JDavis insituHet3D diffhist +1,484 Vilas talk contribs (Created page with "== Citation == J. Carrion, and J. Davis, "Resolving structural heterogeneity in situ through cryogenic electron tomography", Current Opinion in Structural Biology, Volume 96, 103188, 2026 == Abstract == Cryogenic electron tomography (cryoET) has emerged as a powerful tool for studying the structural heterogeneity of proteins and their complexes, offering insights into macromolecular dynamics directly within cells. Driven by recent computational advances, including pow...")
N    06:35  2025Balanov Confirmation diffhist +2,316 WikiSysop talk contribs (Created page with "== Citation == Balanov, A., Bendory, T. and Huleihel, W. 2025. Confirmation bias in Gaussian mixture models. IEEE Trans. on Information Theory. (2025). == Abstract == Confirmation bias, the tendency to interpret information in a way that aligns with one’s preconceptions, can profoundly impact scientific research, leading to conclusions that reflect the researcher’s hypotheses even when the observational data do not support them. This issue is especially critical i...")

18 February 2026

N    07:26  2026Li Atomic diffhist +1,122 WikiSysop talk contribs (Created page with "== Citation == Li, T. and Huang, S.-Y. 2026. Deep learning–based postprocessing and model building for cryo-electron microscopy maps. Current Opinion in Structural Biology. 96, (2026), 103196. == Abstract == Cryo-electron microscopy (cryo-EM) has emerged as one of the most powerful techniques for determining the structures of biological macromolecules. The ultimate goal of cryo-EM is to determine the atomic structure of target molecules, where map postprocessing and...")

17 February 2026

N    04:51  2026Chen CryoEvoBuild diffhist +1,489 WikiSysop talk contribs (Created page with "== Citation == Chen, J., Li, T., He, J. and Huang, S.-Y. 2026. Protein model building for intermediate-resolution cryo-EM maps by integrating evolutionary and experimental information. Structure. 34, (2026), 375–384. == Abstract == Accurate model building in intermediate-resolution cryo-EM maps normally requires flexible fitting of reliable initial structures. However, while deep learning-based methods such as AlphaFold2 can predict highly accurate structures, the p...")
N    04:38  2026Urzhumtsev ProjDir diffhist +1,148 WikiSysop talk contribs (Created page with "== Citation == Urzhumtsev, A.G. 2026. Quantifying distributions of cryo-EM projections. Biological Crystallography. 82, 2 (2026). == Abstract == In cryo-electron microscopy, a set of two-dimensional projections collected from different viewing directions may complicate image processing and subsequent model building if the distribution of these views is non-uniform. View distributions are traditionally represented as color-coded two-dimensional diagrams. However, such...")
N    04:30  2026Barchet NonUniform diffhist +1,627 WikiSysop talk contribs (Created page with "== Citation == Barchet, C., von Loeffelholz, O., Bahena-Ceron, R., Klaholz, B.P. and Urzhumtsev, A.G. 2026. Explicit correction of severely non-uniform distributions of cryo-EM views. Biological Crystallography. 82, 2 (2026). == Abstract == The quality of three-dimensional macromolecular image reconstruction by cryo electron microscopy (cryo-EM) strongly depends on the number and the quality of the respective two-dimensional projections and on their angular distributi...")